RAMS (Raman-Activated Microfluidic Sorter)

Applications

Soil Microbiome Analysis.
Active Bacteria Identification in Seawater.
Efficiently Mining of Microbial Resources.
Rapid Antimicrobial Sensitivity Testing (AST) for Oral Microbiota.
AST and Source Tracking of H. pylori in Gastric Mucosal Samples.
Quality Inspection of Probiotic Products.

Key Features

• •Rapid, label-free profiling of metabolic phenotypes at single-cell resolution
• •Singe-cell Raman Spectra (SCRS) can readily distinguish microbial species and reveal catabolism, anabolism, metabolite-interaction network, stress/drug response, and interaction of cells simultaneously.
• •Single-cell DNA/RNA extraction and amplification with low bias and high genomic coverage
• •Cells isolated with RAMS are ideal for single-cell sequencing with reduced MDA amplification bias. The genome coverage of single E. coli cells can reach up to 99.5%, a significant increase over classical approaches (23%).
• •Precise and automated acquisition of target cells while maintaining biological activity
• •Maintain full visibility throughout the process. RAMS can precisely control the movement trajectory of target cells with optical tweezers, and encapsulate each cell into a microliter-scale microdroplet with minimal impact on biological activity.